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【英文标准名称】:Plasticsrulers
【原文标准名称】:塑料尺
【标准号】:JISS6032-1993
【标准状态】:作废
【国别】:日本
【发布日期】:1993-03-01
【实施或试行日期】:
【发布单位】:日本工业标准调查会(JISC)
【起草单位】:TechnicalCommitteeonConsumerLifeProducts
【标准类型】:()
【标准水平】:()
【中文主题词】:塑料和橡胶技术;绘图室设备;塑料;直尺;文化用品
【英文主题词】:rulers;stationery;drawingofficeequipment;;
【摘要】:
【中国标准分类号】:Y54
【国际标准分类号】:97_180
【页数】:12P;A4
【正文语种】:日语


【英文标准名称】:CharpyImpactTestonThinSpecimensofPolyethyleneUsedinPressurizedPipes
【原文标准名称】:密封管用聚氯乙烯薄试样摆锤冲击试验
【标准号】:ANSI/ASTMF2131-2003
【标准状态】:作废
【国别】:美国
【发布日期】:2002-12-10
【实施或试行日期】:
【发布单位】:美国国家标准学会(US-ANSI)
【起草单位】:ASTM
【标准类型】:()
【标准水平】:()
【中文主题词】:
【英文主题词】:Charpyimpacttests;Impacttests;Polyethylene;Pressurepipes;Specimens;Thin
【摘要】:Thistestmethoddescribesthemethodusedandthecalculationofresultsforthedeterminationofthein-vitrobiologicalactivityofrhBMP-2usingthemousestromalcelllineW-20clone17(W-20-17).ThisclonewasderivedfrombonemarrowstromalcellsoftheW++mousestrain.Thistestmethod(assay)hasbeenqualifiedandvalidatedbasedupontheInternationalCommitteeonHarmonizationassayvalidationguidelines(withtheexceptionofinterlaboratoryprecision)fortheassessmentofthebiologicalactivityofrhBMP-2.Therelevanceofthisinvitrotestmethodtoinvivoboneformationhasalsobeenstudied.ThemeasuredresponseintheW-20bioassay,alkalinephosphataseinduction,hasbeencorrelatedwiththeectopicbone-formingcapacityofrhBMP-2intheinvivoUseTest(UT).rhBMP-2thatwaspartiallyorfullyinactivatedbytargetedperaceticacidoxidationofthetwomethionineswasusedasatooltocomparetheactivities.OxidationofrhBMP-2withperaceticacidwasshowntobespecificallytargetedtothemethioninesbypeptidemappingandmassspectrometry.ThesemethioninesresideinahydrophobicreceptorbindingpocketonrhBMP-2.Oxidizedsampleswerecomparedalongsideanincubationcontrolandanativecontrol.The62,87,98,and100%oxidizedsampleshadW-20activitylevelsof62,20,7,and5%,respectively.Theincubationandnativecontrolsamplesmaintained100%activity.SampleswereevaluatedintheUTandshowedasimilareffectofinactivationonbone-formingactivity.Thesampleswith62%and20%activityintheW-20assaydemonstratedreducedlevelsofboneformation,similarinlevelwiththereductioninW-20specificactivity,relativetotheincubationcontrol.Littleornoectopicbonewasformedinthe7and5%activerhBMP-2implants.Thus,modificationstotherhBMP-2moleculeinthereceptorbindingsitedecreasetheactivityinboththeW-20andUTassays.ThesedatasuggestthatasinglereceptorbindingdomainonrhBMP-2isresponsibleforbothin-vitroandin-vivoactivityandthattheW-20bioassayisarelevantpredictorofthebone-formingactivityofrhBMP-2.ThevaluesstatedinSIunitsaretoberegardedasstandard.Thisstandarddoesnotpurporttoaddressallofthesafetyconcerns,ifany,associatedwithitsuse.Itistheresponsibilityoftheuserofthisstandardtoestablishappropriatesafetyandhealthpracticesanddeterminetheapplicabilityofregulatorylimitationspriortouse.
【中国标准分类号】:G31
【国际标准分类号】:07_080
【页数】:
【正文语种】:英语